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The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin

Our data demonstrate that the Aβ rich brain environment ... has implications for the role of myeloid cells in disease and the utilization of these cells in Alzheimer’s disease therapy. read more

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Targeting microglia in brain disorders

Microglia are specialized tissue-resident macrophages in the central ... Microglia are highly dependent on environmental signals to maintain their homeostatic phenotype. This results in distinct brain ... read more

Glioblastoma-associated Microglia and Macrophages: Targets for Therapies to Improve Prognosis

Brain. 2017;140(6):1548-1560. Overall, monocyte-derived macrophages and CNS-intrinsic microglia are both represented within glioblastoma multiforme specimens in patients and in models. This has ... read more

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Immune modulation of hair follicle regeneration

This review will begin by briefly summarizing the various immune cells resident ... environment conducive for cyclical regeneration through coordinated efforts with commensal microbes. Are ... read more

New type of immune cell discovered in breast ducts

Most organs in the body including the brain, liver, lung, skin and intestine have their own population of macrophages -- a name of Greek origin that ... have dangerous implications for the growth ... read more

Beyond the Byline: Celebrating birthdays

Little Billy O’Boyle rides his new bike through his kitchen during his 6th birthday celebration. Billy O’Boyle sits at the table with his cousin Claire Kraszewski, and friends Walter Roman and ... read more

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Science, this issue p. eaai8478 Tumor fitness, evolution, and resistance to therapy ... macrophages also differ between IDH-A tumors of different grades. Our study redefines the cellular composition ... read more

Capitol Roundup: Legislators take issue with Wolf’s economic reopening plan

Capitol Roundup: Legislators take issue with Wolf’s economic reopening plan May 16, 2020 WILKES-BARRE — State Sen. John Yudichak this week said the absence of transparency in how businesses ... read more

What do we mean by the term “inflammation”? A contemporary basic science update for sports medicine

The major advances in the understanding of inflammation in recent years are summarised, and some clinical implications of the contemporary model of inflammation are highlighted. Despite the widespread ... read more

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

They were interviewed at home by trained interviewers on a wide range of topics, including socioeconomic background, medical history ... the benefits of such therapy outweigh the potential ... read more

American Journal of Respiratory and Critical Care Medicine

COVID-19 is a form of Coronavirus disease due to the novel virus SARS-CoV-2 that causes acute infection with respiratory symptoms. This page will serve as a hub for all COVID-19 related manuscripts ... read more

Neurobiologic Advances from the Brain Disease Model of Addiction

We also review the ways in which social environments, developmental stages, and genetics are intimately linked to and influence ... and profound. Implications of the Brain Disease Model of ... read more

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