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Study: Chemotherapy Drugs May Promote Muscle Mitochondrial Dysfunction - Latest News


Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction ... some people with breast cancer experience through the course of disease treatment. The study is published ahe... read more

Technique could help identify patients who would suffer chemo-induced heart damage

These cells provide researchers with a sorely needed platform to study the effects of doxorubicin exposure on human heart muscle cells, and may allow them to one day predict which patients should avoi... read more

Chemo-Boosting Drug Discovered for Leukemia

In this study, these drugs reversed bone marrow leaks in tissue from mice and humans, and also boosted chemotherapy effects. Since these drugs are already in clinical trials for other applications, th... read more

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Safety of Systemic Chemotherapy in a Patient With Mitochondrial Myopathy and Non–Small-Cell Lung Cancer

mtDNA mutations may lead to the coexistence of wild-type and mutated mitochondrial ... and did not increase significantly over time (Fig 1; AUC, area under the curve). Tumor assessment after three cyc... read more


Don’t Be a Zombie: Senolytics, Exercise and Fasting Fight Off Senescent Cells

Based on a 2010 study from the Journal of the American Geriatrics Society, 45% of people over the age of 85 today are frail, often suffering physical dysfunction and decreased mobility that may lead t... read more

Oxygen deprivation counters deadly mitochondrial disease in animals

But biology is complicated, and researchers hoping to treat diseases in which our cells’ energy-providing machinery is faulty now suggest the opposite may ... [Food and Drug Administration]–approved t... read more

Senolytic Drugs Increase Lifespan, Improve Physical Function in Aging Mice

Senescent cells increase ... study published this week in the journal Nature Medicine, a team of researchers found that treatment with a combination of two senolytic drugs — dasatinib plus quercetin — ... read more

Extended Chemo Extends Life for Children With Rare Cancer

SUNDAY, June 3, 2018 (HealthDay News) -- Children suffering from rhabdomyosarcoma, a rare cancer of the muscle tissue, may have better chances for a cure if they have extended chemotherapy, a new stud... read more

Do Statins Make It Tough to Exercise?

For years, physicians and scientists have been aware that statins, the most widely prescribed drugs in the world, can cause muscle ... dysfunction; mitochondrial respiratory rates were about 25 percen... read more

Cell protein offers new hope in fighting the effects of aging

The discovery could offer a new target for drugs that may help to slow the debilitating effects ... the scientists separated out all the proteins found within the mitochondria of brain cells and muscl... read more

Biotech Analysis Central Pharma News: Conatus Leaps On Upgrade, Reata Fails Mid-Stage Study, Synergy's Strategy Shift

Conatus Pharmaceuticals rises on analyst upgrade, liver disease data expected by Q2 2018. Reata Pharmaceuticals' fails mid-stage study for rare muscle ... in mitochondrial diseases patients suffer fro... read more

Drug Shows Promise Against Rare, Aggressive Skin Cancer

TUESDAY, April 19, 2016 (HealthDay News) -- A newer drug that boosts the immune system's ability to kill tumor cells may help people with ... who led the new study. When the disease reaches an advance... read more



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