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Stabilizing Dysferlindeficient Muscle Cell Membrane Improves Muscle Function - Latest News


Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

Healthy muscle cells rely on the protein dysferlin to properly repair the sarcolemmal membrane, a thin specialized membrane that serves a vital role in ensuring that muscle fibers are strong enough an... read more

Gene technique offer possible hope for muscular dystrophy

Gene therapy using adeno-associated virus (AAV) to deliver genes to cells ... leg muscles of dysferlin-deficient mice using both intramuscular and vascular approaches to further evaluate whether the g... read more

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of the cell membrane repair machinery. Here, we examined the translational value of targeting MG53 function in .. ... read more

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Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair

Primary cultured myoblasts and myotubes established from patient muscle biopsies have ... in fibroblasts from dysferlin-deficient patients and SJL mice was analyzed by immunoblotting and immunocytoche... read more


Carmeseal-MD™ Protects Skeletal Limb Muscle, the Third Major Target Muscle of Therapeutic Relevance in Duchenne Muscular Dystrophy (DMD)

About Carmeseal-MD™ Carmeseal-MD (Poloxamer 188 NF or P-188 NF) is the first disease modifying agent in diseases characterized by membrane ... been shown to improve the performance of damaged diaphrag... read more

Tenax Therapeutics Is Tackling Critical Care With Levosimendan

It has been proposed that this triple MOA also helps to preserve heart function during cardiac surgery, and studies have demonstrated that levosimendan protects the heart and improves tissue ... or he... read more

Exploring how lipids in our bodies and cell membranes affect aging and long-term health

A professor at Worcester Polytechnic Institute (WPI) is exploring aging on the molecular level, examining how the lipids found in our bodies, particularly those in our cell membranes, change as we age ... read more

New gene transfer strategy shows promise for limb girdle and other muscular dystrophies

Gene therapy using adeno-associated virus (AAV) to deliver genes to cells ... leg muscles of dysferlin-deficient mice using both intramuscular and vascular approaches to further evaluate whether the g... read more

The moral mathematics of second-string medicine in West Africa

Ketamine, a tranquilizer commonly used for animals, is notorious for causing muscle spasms ... circle in the outermost membrane of her lens and gently suck out its cloudy contents with a modified syri... read more

Dystrophic heart failure blocked by membrane sealant poloxamer

Control (C57BL/10 SnJ) and mdx (C57BL/10 ScSn-mdx) mice obtained from Jackson Laboratories were maintained in barrier isolation facilities at the University of Michigan. The procedures used in this st... read more

Carmeseal-MD(TM) Protects Skeletal Limb Muscle, the Third Major Target Muscle of Therapeutic Relevance in Duchenne Muscular Dystrophy (DMD)

Previously, Carmeseal-MD had been shown to improve the performance of dystrophic heart and diaphragm damaged by the lack of dystrophin, a key structural membrane protein. Carmeseal-MD, a membrane stab... read more

Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion

However, in a living cell, intramembrane proteases function in ... any possible role of membrane organization or the underlying cytoskeleton on rhomboid mobility. Treating cells with microtubule desta... read more



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