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Stabilizing Dysferlindeficient Muscle Cell Membrane Improves Muscle Function - Latest News


Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

WASHINGTON-(Aug. 27, 2018)-Healthy muscle cells rely on the protein dysferlin to properly repair the sarcolemmal membrane, a thin specialized membrane that serves a vital role in ensuring that muscle ... read more

New gene transfer strategy shows promise for limb girdle and other muscular dystrophies

Gene therapy using adeno-associated virus (AAV) to deliver genes to cells ... leg muscles of dysferlin-deficient mice using both intramuscular and vascular approaches to further evaluate whether the g... read more

Carmeseal-MD(TM) Protects Skeletal Limb Muscle, the Third Major Target Muscle of Therapeutic Relevance in Duchenne Muscular Dystrophy (DMD)

Previously, Carmeseal-MD had been shown to improve the performance of dystrophic heart and diaphragm damaged by the lack of dystrophin, a key structural membrane protein. Carmeseal-MD, a membrane stab... read more

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Researchers describe how cells take out the trash to prevent disease

The ARTs are found in both yeast and humans, suggesting the fundamental nature of their function. Once the protein is tagged, the piece of membrane with the targeted protein forms a packet, called a v... read more

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The structural basis of blebbistatin inhibition and specificity for myosin II

The identification of new myosin-specific cleft-binding derivatives not only would provide valuable tools for dissecting complex biological processes of cell motility and muscle contraction, but also ... read more

Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

In a head-to-head trial between the conventional glucocorticoid, prednisolone, and a modified glucocorticoid, vamorolone, in experimental models of LGMD2B, vamorolone improved dysferlin-deficient musc... read more

'Weight training' muscles reduce fat, improve metabolism in mice

Using a mouse genetic model, BUSM researchers demonstrated that an increase in type II muscle mass can reduce body fat which in turn reduces overall body mass and improves metabolic ... in the Februar... read more

Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

In a head-to-head trial between the conventional glucocorticoid, prednisolone, and a modified glucocorticoid, vamorolone, in experimental models of LGMD2B, vamorolone improved dysferlin-deficient musc... read more

Ischemia and reperfusion—from mechanism to translation

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, ci... read more

Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

Lack of dysferlin is associated with increased lipid mobility in the limb girdle muscular dystrophy type 2B (LGMD2B) cell membrane, which is further increased by injury and prednisolone treatment, cau... read more



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