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Stabilizing Dysferlindeficient Muscle Cell Membrane Improves Muscle Function - Latest News


Stabilizing dysferlin-deficient muscle cell membrane improves muscle function

Lack of dysferlin is associated with increased lipid mobility in the limb girdle muscular dystrophy type 2B (LGMD2B) cell membrane, which is further increased by injury and prednisolone treatment, cau... read more

Gene technique offer possible hope for muscular dystrophy

Gene therapy using adeno-associated virus (AAV) to deliver genes to cells ... leg muscles of dysferlin-deficient mice using both intramuscular and vascular approaches to further evaluate whether the g... read more

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of the cell membrane repair machinery. Here, we examined the translational value of targeting MG53 function in .. ... read more

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Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair

Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair. PLOS Currents Muscular Dystrophy ... Primary cultured myoblasts and myotubes established from patient muscle biopsies have been wid... read more


Carmeseal-MD(TM) Protects Skeletal Limb Muscle, the Third Major Target Muscle of Therapeutic Relevance in Duchenne Muscular Dystrophy (DMD)

Previously, Carmeseal-MD had been shown to improve the performance of dystrophic heart and diaphragm damaged by the lack of dystrophin, a key structural membrane protein. Carmeseal-MD, a membrane stab... read more

New gene transfer strategy shows promise for limb girdle and other muscular dystrophies

Gene therapy using adeno-associated virus (AAV) to deliver genes to cells ... leg muscles of dysferlin-deficient mice using both intramuscular and vascular approaches to further evaluate whether the g... read more

Tenax Therapeutics Is Tackling Critical Care With Levosimendan

It has been proposed that this triple MOA also helps to preserve heart function during cardiac surgery, and studies have demonstrated that levosimendan protects the heart and improves tissue ... or he... read more

Twenty-five year hunt uncovers heart defect responsible for cardiovascular diseases

"Our research has revealed that a genetic alteration in the largest membrane protein, responsible for triggering ... the pulse of calcium release that is required for each heart muscle cell to contrac... read more

The moral mathematics of second-string medicine in West Africa

Ketamine, a tranquilizer commonly used for animals, is notorious for causing muscle spasms ... circle in the outermost membrane of her lens and gently suck out its cloudy contents with a modified syri... read more

Carmeseal-MD™ Protects Skeletal Limb Muscle, the Third Major Target Muscle of Therapeutic Relevance in Duchenne Muscular Dystrophy (DMD)

About Carmeseal-MD™ Carmeseal-MD (Poloxamer 188 NF or P-188 NF) is the first disease modifying agent in diseases characterized by membrane ... been shown to improve the performance of damaged diaphrag... read more

Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function

2 CNC–Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. 3 INSERM U1170, Gustave Roussy Cancer Center, Villejuif, France. 4 Faculty of Medicine, Université Paris-Sud, ... read more

Plasma membrane–associated platforms: Dynamic scaffolds that organize membrane-associated events

Specialized regions of the plasma membrane dedicated to diverse ... does not abolish secretion in nonneuronal cells, indicating that the role of neuronal and nonneuronal PMAPs is to spatially confine ... read more



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