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Sitagliptin Improves Glycemic Profile In Type 2 Diabetes Mild Renal Impairment - Latest News


Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use

People with type 2 diabetes have reduced circulating levels of GLP-1 but retain their ability to respond to this hormone. Thus, it is possible to improve glycemic control ... with moderate to severe r... read more

Merck Presents New Data from the Comparative Trials with Sitagliptin (CompoSIT) Clinical Trial Program with JANUVIA® (sitagliptin)

“These studies further support the clinical profile of JANUVIA ... Safety and Efficacy of Sitagliptin Compared with Dapagliflozin in Subjects with Type 2 Diabetes, Mild Renal Impairment and Inadequate ... read more

Lexicon Pharmaceuticals' CEO Discusses Q2 2013 Results - Earnings Call Transcript

The first that I’ll be reviewing with you is the 30-patient study of LX4211 in patients with type 2 diabetes and renal impairment ... I’ll show you are well below the doses required to improve glycemi... read more

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Current Therapeutic Drugs for Type 2 Diabetes, Still Useful After 50 Years?

The primary aim of managing Type 2 diabetes is to delay, or even prevent, the complications of the disease by achieving good glycemic control ... moderate renal impairment (with a reduced dose), and m... read more


The Role of α-Cell Dysregulation in Fasting and Postprandial Hyperglycemia in Type 2 Diabetes and Therapeutic Implications

Studies utilizing these tools to establish the function of glucagon in normal nutrient homeostasis and to document a relative glucagon excess in type 2 diabetes ... importance of α-cell dysregulation ... read more

Elcelyx 'Guts' Conventional Thinking on Metformin

The company plans to initiate a pharmacokinetic study this summer in Type II diabetes patients with mild, moderate and severe renal impairment ... 2 inhibitor, provided greater improvements in blood g... read more

FDA Advisory Committee Recommends the Investigational SGLT2 Inhibitor Dapagliflozin for the Treatment of Type 2 Diabetes in Adults

Dapagliflozin is being reviewed by the FDA for use as monotherapy, and in combination with other antidiabetic agents, as an adjunct to diet and exercise to improve glycemic control in adults with type ... read more

The Ideal Diabetes Therapy: What Will It Look Like? How Close Are We?

Today, 11 classes of diabetes drugs are available, and many more are in development. Despite this increase, diabetes was the leading cause of blindness, kidney failure ... effective long-term glycemic ... read more

Ozempic® approved in Canada for the treatment of adults with type 2 diabetes

as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, when metformin is not tolerated or contraindicated. 1 Ozempic ®, a once-weekly glucagon-like pep... read more

Lexicon Pharmaceuticals' CEO Discusses Q4 2011 Results - Earnings Call Transcript

In addition to this we’ve initiated a proof-of-concept study and type 2 diabetes patients who have moderate to severe renal impairment ... like in the mild studies we see a synergistic elevation of ac... read more



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