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Sglt2 Inhibitoramputation Link In Diabetes Is It Hypovolemia - Latest News


SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia?

BERLIN – Use of diuretics may increase the risk for lower limb amputations in people with diabetes, and the same hypovolemic effect might help explain the increased risk of amputations seen with the ... read more

FDA Warns of Ketoacidosis With Newer Diabetes Drugs

The morbidity and mortality related with diabetes arises as a result of microvascular and macro-vascular complications. Recently, FDA has issued warning against the use of SGLT2 (Sodium-Glucose Linked ... read more

SGLT2 inhibitors in the management of type 2 diabetes

The glucose-lowering pharmacopeia continues to grow for patients with type 2 diabetes ... SGLT2 inhibitor will be safe and efficient enough as add- on therapy on insulin due to its noninsulin ... read more

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Forxiga decreases HbA1c and body weight but not without risks

Forxiga is a type 2 diabetes drug within the SGLT-2 inhibitors class of diabetes medications ... notably thiazolidinediones (such as Actos), have been linked with increased risks of heart problems. ... read more


Diabetes Mellitus Type 2 News

Medscape Medical News, October 2018 EASD 2018SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia? Observational study finds ... Top-line data from DECLARE-TIMI 58 hint that CV benefit of ... read more

Xigduo XR by AstraZeneca

The FDA has approved Xigduo XR (dapagliflozin and metformin HCl extended-release tablets) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus ... ... read more

Renal glucose transporters: novel targets for hyperglycemia management

One such class of agents under development for the treatment of diabetes is the sodium-dependent glucose transporter (SGLT)2 inhibitors that inhibit the major glucose transport proteins in the ... read more

Bolstering your armamentarium with SGLT2 inhibitors

31,41 The ADA/European Association for the Study of Diabetes position statement recommends that SGLT2 inhibitors can be used at any stage of T2DM in dual or triple combination with other oral and ... read more

Regulation of renal glucose transporters during severe inflammation

We found a decreased plasma glucose concentration with impaired renal tissue perfusion and GFR and increased fractional glucose excretion associated with decreased expression of SGLT2 ... of tubular ... read more

The SGLT2 Inhibitor-Amputation Link

There has been much excitement in the type 2 diabetes ... reported this link." The absolute risk difference was small: 4.9/10,000 person years for the sulfonylureas, metformin, and thiazolidinediones ... read more

Addressing the Risk of Cardiovascular Mortality in Patients with Type 2 Diabetes

Of adults with diagnosed diabetes ... SGLT2 inhibitors, including JARDIANCE; some reports involved patients younger than 65 years of age. Before initiating JARDIANCE, consider factors that may ... read more

Dapagliflozin - Indications, Dosage, Side Effects and Precautions

Dapagliflozin is a sodium - glucose cotransporter 2 inhibitor (SGLT2) which is prescribed to lower the blood sugar levels in patients with type 2 diabetes ... irbesartan as dapagliflozin can lead to ... read more



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