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Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound

Treatment ... 5′ stem-loop RNA sequence of human collagen α1(I) mRNA was labeled at the 5′ end by fluorescein and was synthesized by Dharmacon (fl-5′SL RNA). 25.6 nM of LARP6* and 1 nM of fl-5′SL RNA ... read more

Treating Newly Diagnosed High-Risk Smoldering Myeloma

But I really look forward to all of this other data, like the exome sequencing and ... re not quite there yet for treatment. Now Dr Mateos is paving the way in telling us that you probably should cons... read more

Color to Move Whole Genome Sequencing Into Clinical Care through 100,000-Person Initiative Focused on Polygenic Risk

SAN FRANCISCO: Color announced an initiative to help build the foundation for the first mainstream application of whole genome sequencing in clinical ... cancer and heart disease in order to optimize ... read more

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Secondary Hormone Therapy for Castration-Resistant Prostate Cancer

[15] The key to optimizing secondary hormonal therapy sequencing ... Regan MM, Ko YJ, et al. Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymp... read more

AmorChem invests in project to advance new RNA technology

“This collaboration will allow all partners to gain a deeper understanding of RNA sequencing ... of treatment options and a meaningful economic impact,” says Jacques Simoneau, CEO of Univalor. About A... read more

Call-to-Action Optimization: 132% increase in clickthrough from changing four simple words

Both treatments improved clickthrough rate (CTR), with the second treatment ... optimization efforts to help improve the probability of conversion (“C” in the below image). Motivation of the prospecti... read more

DNA Testing may Soon be Routine for Patients with Kidney Disease

Genes are responsible for about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has an immediate impact on treatment for most ... results suggest that genomic s... read more

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Since the discovery of cisplatin in the early 1960’s, considerable efforts have been ... The data we generated provide a platform for further research on optimizing cisplatin treatment efficacy and re... read more

Aveo's Inflection Point: Tivozanib Likely To Receive Positive Advisory Vote, FDA Approval

Tivozanib is a potent, selective, long half-life inhibitor of VEGF receptors 1,2 and 3 that is designed to optimize VEGF blockade while minimizing off-target toxicities. Several agents targeting VEGF ... read more

Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia

Clinical features include virilization, early gonadotropin-independent precocious ... anastrozole, in an attempt to optimize his growth. After the initiation of this treatment, the patient’s growth ra... read more

For patients with kidney disease, genetic testing may soon be routine

A new study has found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment for most ... results suggest that ... read more

Peptide Receptor Radionuclide Therapy for NETs

Can you tell the audience a bit about the treatment and when you think it should ... I think that this will be a good study to sort of give us early indications of how to potentially sequence treatmen... read more

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