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New Principle For Activation Of Cancer Genes Discovered - Latest News

New methods help to accurately identify cancers’ hidden genetic losses, duplications

Understanding the specific mutations that contribute to different forms of cancer is critical to improving diagnosis and treatment. read more

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Algorithms uncover cancers' hidden genetic losses and gains

Limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes. Now, methods developed by ... read more

Potential Biomarker Discovered for Diagnosing Early-Stage Cancer

This research is a proof-of-principle ... undiagnosed cancer is still experimental. The new study focuses on examining proteins contained in EVPs rather than analyzing genes. read more

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Notorious Cancer Gene May Work By Destroying Messenger

COLUMBUS , Ohio A new study suggests how a notorious cancer gene may contribute ... between Src and cancer was discovered 30 years ago, but to this day, we still don't know its exact role in tumor ... read more

Promising phase 1 trial results: Use of sotorasib (AMG 510) in patients with solid tumors

A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a ... read more

New Targets for Treatment of Triple-Negative Breast Cancer Discovered

Four new subtypes of ... can be thought of as the cancer 'ecosystem' that supports a tumor to grow and spread," said Sunny Wu, PhD, first author of the study, in a press release. 2 In order to create ... read more

Sotorasib (AMG 510) Shows Promising Results in Some Patients With Solid Tumors, Suggests a Study With City of Hope as a Co-Lead Author

A phase 1 clinical trial of AMG 510 in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity. read more

A pan-cancer assessment of alterations of the kinase domain of ULK1, an upstream regulator of autophagy

Autophagy is a key clearance process to recycle damaged cellular components. One important upstream regulator of autophagy is. Several three-dimensional structures of ... read more

Activating 'STING' Against Cancer

Molecule that can activate a natural immune-boosting protein called STING was discovered by a group ... that aid in prevention and treatment of cancer. New Anti-cancer Protein Biomarker Identified ... read more

Opdivo trial offers new insights into how immuno-oncology drugs could be enhanced

By analyzing tumor samples from a study of Bristol Myers Squibb's Opdivo in melanoma patients, a research team led by UCLA scientists showed that inducing interferon signaling could be part of a ... read more

Mutations in Novel Gene Associated with Primary Lymphedema

Reseachers have made an important discovery into how mutations in a novel gene, ANGPT2, cause a lymphatic disease called primary lymphedema. read more

New insights into drug resistance in small cell lung cancer

“We were able to definitively show that activation of a single gene can cause a complete switch ... resistance in mouse models of small cell lung cancer that use patient-derived tumor tissue. They ... read more

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