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Muscle-building proteins hold clues to ALS, muscle degeneration

Physician-scientists and competitive runners Josh Wheeler, left, and Thomas Vogler on the summit of Long's Peak in Colorado. Credit: CU Boulder Toxic protein assemblies, or "amyloids," long considered ... read more

Neuron death in ALS more complex than previously thought

PROVIDENCE, R.I. [Brown University] — Brown University researchers have uncovered new clues about the ... journal PLOS Genetics. ALS is characterized by the degeneration of motor neurons in the spine ... read more

Potential drug targets for ALS revealed in study using CRISPR

ALS, also known as Lou Gehrig’s disease, erodes muscle function ... against the toxic protein. Not only did some genes give the researchers a deeper mechanistic understanding of the disease itself; a ... read more

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Cialis Comes Full Circle — Help for Muscular Dystrophy

It must nestle into the smooth muscle cell’s outer membrane (sarcolemma) to produce the needed NO, and another protein, dystrophin ... tone while hibernating — their physiology may hold clues to muscl... read more

New understanding of DNA repair

This new understanding may, in the long term ... Dr Savery said: “It means that we can see the details of the motor, the parts of the protein that grab hold of the polymerase in order to move it, and ... read more

New ALS gene mutation discovered

In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each ... read more

Tiny cellular antennae key to fat formation in muscle

Through a series of experiments, the group discovered that genetically engineering cells without cilia had resulted in a low-level activation of the Hedgehog pathway, which was enough to block fatty d... read more

Deaths and complications due to treating the fake disease known as “chronic Lyme disease”

The patient subsequently died from complications of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting motor neurons. The... read more

What Is Synthetic Pot, and Why's It Causing Heart Attacks in Teenagers?

What’s The News: Three 16-year-old teenage boys in Texas had heart attacks shortly after smoking a product called k2, or Spice, according to a study published this month in the journal Pediatrics. The ... read more

Overexcited neurons not good for cell health

The result of both mutations was overexcited neurons that disrupted the way the neurons sent signals to the muscle ... influencing protein homeostasis,” said Morimoto, an expert on Huntington’s diseas... read more

Muscle-building proteins hold clues to ALS, muscle degeneration

Toxic protein assemblies, or "amyloids," long considered to be key drivers in many neuromuscular diseases, also play a beneficial role in the development of healthy muscle tissue, University of Colora... read more

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