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Mechanical Ventilation May Alter Diaphragm Muscle Fibers - Latest News

Mechanical ventilation may alter diaphragm muscle fibers

(HealthDay)—In critically ill patients, mechanical ventilation with positive end-expiratory pressure (PEEP) results in reduced diaphragm fiber length that may make it more difficult to wean patients f... read more

Mechanical ventilation reduces rat diaphragm blood flow and impairs oxygen delivery and uptake*

Objectives: Although mechanical ventilation is a life-saving intervention in patients ... promote a hypoxia-induced generation of reactive oxygen species in diaphragm muscle fibers and contribute to v... read more

Breathing Muscles Atrophy Quickly During Mechanical Ventilation

Powers of the University of Florida, showed rapid breakdown of diaphragm muscle fibers during ... how sharply mechanical ventilation can lead to decrease in the strength of respiratory muscles." In te... read more

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A Natural History Study Isn’t Necessarily About Dinosaurs

When Technology Extends “Natural” History: Huntington Disease and Pompe Disease Technology may be able to ... disease that gloms up muscle fibers, children who’d been improving once again required mec... read more

Pediatric Autonomic Disorders

The scope of pediatric autonomic disorders is not well recognized ... of management to optimize neurodevelopmental outcome is tracheostomy with mechanical ventilation. 50 Diaphragm pacing is a daytime ... read more

Myasthenia gravis and myasthenic crisis

4,6 An MC results from worsening muscle fatigue and weakness leading to respiratory muscle compromise requiring endotracheal intubation and mechanical ventilation ... may be uncomfortable for the pati... read more

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting

1 Department of Internal Medicine—Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. 2 Wake Forest Critical Illness, Injury and R... read more

The Pathophysiology of Respiratory Impairment in Pediatric Neuromuscular Diseases

This is a summary of the presentation on the pathophysiology of respiratory impairment in pediatric neuromuscular disorders presented ... In other words, a patient with extreme respiratory muscle weak... read more

Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle

Muscle ... diaphragm inactivity and mechanical ventilation,” Levine said. “Disuse atrophy of human diaphragm myofibers could be a major contributor to the weaning problems that occur in some of our pa... read more

Drug Duo Treats ALS – On A Chip

The patient can then choose mechanical ventilation or to let nature take its course. Early symptoms may be overlooked ... the ensuing muscle contraction was robust. But with motor neurons from the ALS ... read more

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

1 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-177 77, Sweden. 2 Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala 75124, Sweden. 3 Cl... read more

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

1 Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. 2 VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA. 3 Lif... read more

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