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Distinct Clinical Subgroups In Early-Onset Colorectal Cancer

Although early-onset colorectal cancer (CRC) is clinically and genetically distinct from standard CRC in adults older than 50, a retrospective review of more than 36,000 patients from four separate ... read more

Colorectal cancer in patients with early onset is distinct from that in older patients

New research indicates that colorectal cancer diagnosed at an early age has clinical and genetic features that are ... cancer have fallen in patients aged 50 years and older, early-onset colorectal ... read more

Does Age at Diagnosis Impact Clinical and Molecular Features of Colorectal Cancer?

Colorectal cancers diagnosed in early adulthood are genetically and clinically distinct, and potentially ... study that seeks to answer very important clinical and molecular questions on early-onset ... read more

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Comment on ‘Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system’

MSI: Microsatellite Instability. EOCRC: Early-onset colorectal cancer. Abbreviations: LOCRC=Late-onset colorectal cancer; SCRC=Synchronous colorectal cancer. A full colour version of this figure is ... read more


Obesity Associated With Risk of Early-onset CRC in Women

New cases of colorectal cancer (CRC ... added that although it cannot be assumed that this early-onset CRC study would translate to other groups, he suspects there would be similar findings with all ... read more

MEK/PD-L1 Inhibition Fails in Third-Line Colon Cancer

"Although many patients with metastatic colorectal cancer who have tumors with high microsatellite instability benefit from clinical improvement after ... was that it was not designed to examine ... read more

Colorectal cancer diagnosed at early age is distinct from that in older patients

Also, among patients with early-onset colorectal cancer, very young patients (aged 18-29 years) were unique from older patients (aged 30-49 years) in terms of the clinical and genetic features of ... read more

Colorectal cancer in patients with early onset is distinct from that in older patients

Also, among patients with early-onset colorectal cancer, very young patients (aged 18-29 years) were unique from older patients (aged 30-49 years) in terms of the clinical and genetic features of ... read more

ASCO GI: Three Molecular Colorectal Cancer Subtypes in New Diagnostic Classification System

Unlike in breast cancer, there is currently no molecular classification of colorectal cancers that facilitates diagnosis, prognosis, and guides treatment choice. The team came up with three distinct ... read more

Mutational interactions define novel cancer subgroups

The key interactions within and across novel subgroups may uncover common ... Similarly, the colorectal subtypes are quite distinct in their cluster composition. For the breast cancer patient samples, ... read more



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