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Chemotherapy Causes Mitochondrial Dysfunction In Skeletal Muscle - Latest News


Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigu... read more

Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice

DMD is characterized by progressive muscle wasting. The absence of dystrophin, a membrane-associated protein, causes disruption of ... in calcium was related to mitochondrial function at this stage of ... read more

Mitochondrial Disease or Medical Child Abuse?

They were looking for a gastroenterologist to help with 14-year-old Justina’s mitochondrial disease, a rare disorder that causes widespread and nonspecific ... mitochondria in the cell membranes of sk... read more

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Muscle Weakness Found in Some Autistic Children

SUNDAY, April 13 (HealthDay News) -- New research suggests that muscle weakness in a ... genetic defects in their skeletal muscles. However, that doesn't mean that 65 percent of children with autism l... read more


Common Physiological Causes of Depression in Chronic Illness and How to Remedy Them

Much medical research of late has linked mitochondrial dysfunction and low energy to ... If something is stressing your ANS, it will also cause momentary distress in, or a weakening of your skeletal m... read more

miRagen Therapeutics and Collaborators Identify Key Role for miR-133a as a Modulator of Skeletal Muscle Disorder

In this study, adult mice lacking miR-133a developed progressive CNM, as well as mitochondrial dysfunction and fast-to-slow myofiber conversion. These findings demonstrate an essential role for miR-13... read more

Young People Prone to Type 2 Diabetes Exhibit Alterations in Mitochondrial Activity

Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of pare... read more

Mitochondrial Dysfunction and Type 2 Diabetes

Type 2 diabetes is the most common metabolic disease in the world. In the United States, it is the leading cause of blindness ... Potential mechanism by which mitochondrial dysfunction induces insulin ... read more

Association between TDP-43 and mitochondria in inclusion body myositis

Inclusion body myositis (IBM) is the most common cause ... skeletal muscle samples from IBM patients. We found that IBM pathological markers TDP-43, phosphorylated TDP-43, and p62 all coexisted with i... read more

Disease-Induced Skeletal Muscle Atrophy and Fatigue

Disease ... causes persistent elevation of circulating TNF, which exerts endocrine actions on skeletal muscle myofibers. TNF binding to TNFR1 stimulates nSMase3-dependent ceramide signaling, which inc... read more

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

Excessive levels of certain saturated fatty acids cause ... resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal Molecular and Cellul... read more



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