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Chemotherapy Causes Mitochondrial Dysfunction in Skeletal Muscle

Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer experience through the course of disease treatment. The study is ... read more

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to ... read more

Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia

Chemotherapy can cause cachexia, which consists of weight ... in the mechanism responsible for GHS beneficial effects in skeletal muscle, strongly indicating that targeting mitochondrial dysfunction ... read more

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Study Shows How Pomegranates May Help Keep Us Younger

Skeletal muscles begin to weaken and lose strength and mass in humans over the age of 50 — but a new study has found that UA can stimulate mitochondrial biogenesis — in effect reversing the ... read more


Mitochondrial Fusion May Explain Alcohol’s Effect on Muscle

Other environmental factors might cause muscle fatigue by affecting mitochondria as well. References: Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling. ... read more

Novel strategy to ameliorate symptoms of mitochondrial disease

Dysfunctional mitochondria can lead to serious diseases, which mostly affect tissues with high energy demands such as brain, skeletal muscle, and heart ... genetic changes - in the mitochondrial DNA. ... read more

New way to tackle mitochondrial disease

Dysfunctional mitochondria can lead to serious diseases, which mostly affect tissues with high energy demands such as the brain, skeletal muscle and heart ... genetic changes – in the mitochondrial ... read more

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

(October 4, 2018)--Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction ... may help alleviate some of the burden of the disease on patients." Read the full article, ... read more

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

"Interventions designed to counter these effects on muscle may help alleviate some of the burden of the disease on patients." American Physiological Society. (2018, October 4). Chemotherapy may lead ... read more

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Sarcopenia is associated with increased morbidity and mortality in chronic kidney disease (CKD). Pathogenic mechanism of skeletal muscle loss ... alterations and mitochondrial disintegration induced ... read more

High-resolution 3D images reveal the muscle mitochondrial power grid

This new information may lead to a better understanding of many diseases linked to energy utilization in the heart and skeletal muscle such as heart disease, mitochondrial diseases ... supports ... read more



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