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Chemotherapy Causes Mitochondrial Dysfunction In Skeletal Muscle - Latest News


Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

"Interventions designed to counter these effects on muscle may help alleviate some of the burden of the disease on patients." American Physiological Society. (2018, October 4). Chemotherapy may lead t... read more

Mitochondrial Disease or Medical Child Abuse?

Mitochondrial disease (Justina Pelletier’s original diagnosis) and medical child abuse (the Boston Children’s diagnosis ... an accumulation of mitochondria in the cell membranes of skeletal muscles. T... read more

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

Excessive levels of certain saturated fatty acids cause ... resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal Molecular and Cellul... read more

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Muscle Weakness Found in Some Autistic Children

SUNDAY, April 13 (HealthDay News) -- New research suggests that muscle weakness in a ... genetic defects in their skeletal muscles. However, that doesn't mean that 65 percent of children with autism l... read more


miRagen Therapeutics and Collaborators Identify Key Role for miR-133a as a Modulator of Skeletal Muscle Disorder

In this study, adult mice lacking miR-133a developed progressive CNM, as well as mitochondrial dysfunction and fast-to-slow myofiber conversion. These findings demonstrate an essential role for miR-13... read more

150-year-old drug might improve cancer radiation therapy, study says

"We found that one dose of papaverine prior to radiation therapy reduces mitochondrial ... been used for erectile dysfunction. The study "represents a potential landmark in the six-decade-old quest to ... read more

Chemotherapy-related leiomyopathy: a suggested morphological explanation for the intestinal dysmotility affecting patients treated with anthracyclines

Tissue samples from the heart, gastrointestinal tract, uterus, urinary bladder, and skeletal ... motility dysfunction associated with their chemotherapy, suggesting that, in addition to the heart, ant... read more

EXercise as a regulator of hepatic NAD metabolism and MItochondrial function in Non-Alcoholic fatty liver disease

Several studies showed that the hepatic NAD metabolism is dysregulated during the development of NAFLD and that exercise has a positive effect on NAD metabolism and function of NAD dependent enzymes i... read more

Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA ... loss-of-function mutat... read more

Chemotherapy for dogs

Weight loss is often the result of something called cancer cachexia – basically it is the disease and not the treatment that causes a progressive loss of fat and skeletal muscle. Chemotherapy can help ... read more

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigu... read more



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