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Chemotherapy Causes Mitochondrial Dysfunction In Skeletal Muscle - Latest News


Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle

Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigu... read more

Mitochondrial Disease or Medical Child Abuse?

They were looking for a gastroenterologist to help with 14-year-old Justina’s mitochondrial disease, a rare disorder that causes widespread and nonspecific ... mitochondria in the cell membranes of sk... read more

Muscle Weakness Found in Some Autistic Children

SUNDAY, April 13 (HealthDay News) -- New research suggests that muscle weakness in a ... genetic defects in their skeletal muscles. However, that doesn't mean that 65 percent of children with autism l... read more

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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

We have previously shown that sustained mTORC1 activation in skeletal muscle blocks autophagy induction and causes a late-onset myopathy ... is not induced upon autophagy impairment or mitochondrial d... read more


miRagen Therapeutics and Collaborators Identify Key Role for miR-133a as a Modulator of Skeletal Muscle Disorder

In this study, adult mice lacking miR-133a developed progressive CNM, as well as mitochondrial dysfunction and fast-to-slow myofiber conversion. These findings demonstrate an essential role for miR-13... read more

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

Excessive levels of certain saturated fatty acids cause ... resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal Molecular and Cellul... read more

Young People Prone to Type 2 Diabetes Exhibit Alterations in Mitochondrial Activity

Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of pare... read more

Free fatty acids and skeletal muscle insulin resistance

Purpose of review Acute exposure to fatty acids causes ... pathways, mitochondrial dysfunction and oxidative stress have also been put forward as major contributors to the development or maintenance o... read more

Technique could help identify patients who would suffer chemo-induced heart damage

The failing heart function is due to the death of the cells in the organ’s muscle tissue. This dilemma places patients in a medical Catch-22, having been cured from cancer but later suffering heart di... read more

Q2 2018 Biotech Catalyst Watchlist: Phase 3 Clinical Trials

Also, statins come with significant adverse side effects most commonly affecting the patient’s skeletal muscles ... cure for Alzheimer’s Disease, a chronic, incurable, progressive, neurodegenerative d... read more

Mitochondrial Dysfunction and Type 2 Diabetes

Type 2 diabetes is the most common metabolic disease in the world. In the United States, it is the leading cause of blindness ... Potential mechanism by which mitochondrial dysfunction induces insulin ... read more



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