Caf Hierarchy Driven By Pancreatic Cancer Cell P53status Creates A Prometastatic And Chemoresistant Environment Via Perlecan | Latest News RSS feed

Caf Hierarchy Driven By Pancreatic Cancer Cell P53status Creates A Prometastatic And Chemoresistant Environment Via Perlecan - Latest News


CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarchy ... of the cancer cell p53 status) by creating a ... read more

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Targeting Perlecan Reduced Spread of Pancreatic Cancer and Improved Response to Chemo

the study (“CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan”), published in Nature Communications, may provide a ... read more

Key to targeting the spread of pancreatic cancer

Targeting the tissue around pancreatic cancer cells may be the key to stopping their spread and improving chemotherapy outcomes. An international team of researchers has revealed how aggressive ... read more

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SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

We show that SerpinB2 is required by stromal cells for normal collagen remodelling in vitro, regulating fibroblast interaction and engagement with collagen in the contracting matrix. In a pancreatic ... read more



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