Caf Hierarchy Driven By Pancreatic Cancer Cell P53status Creates A Prometastatic And Chemoresistant Environment Via Perlecan | Latest News RSS feed

Caf Hierarchy Driven By Pancreatic Cancer Cell P53status Creates A Prometastatic And Chemoresistant Environment Via Perlecan - Latest News


CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs. We reveal the existence of a p53-driven hierarchy ... of the cancer cell p53 status) by creating a ... read more

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Targeting Perlecan Reduced Spread of Pancreatic Cancer and Improved Response to Chemo

the study (“CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan”), published in Nature Communications, may provide a ... read more

Key to targeting the spread of pancreatic cancer

The researchers discovered that some pancreatic tumours produce more of a molecule called 'perlecan' to remodel the environment around them, which helps cancer cells spread more easily to other parts ... read more



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