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Hormonal Mechanism Could Explain Canagliflozin's Fracture Risk

The elevated fracture risk seen with the type 2 diabetes drug canagliflozin (Invokana, Janssen) appears to be a class effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors and is potentially modifiable, new research suggests. The findings, from a ... read more

The vitamin D paradox in Black Americans

Instead, vitamin D is converted to a pre-hormone ... could fully explain the significance of low measures of vitamin D status with respect to skeletal health in Black Americans. A better understanding of these factors may be key to understanding mechanisms ... read more

Happy hormone's calcium connection may make cows and humans healthier

In fact, non-lactating women, men and children who take SSRIs show signs of increased fracture risk ... could then be further exacerbated if the mother is taking an SSRI. Fortunately, Hernandez's research on a different disease in another species helps to ... read more

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High-tech imaging could reveal mysteries of bone damage in kids with chronic disease

Walking him back to the waiting room, she asked how he wanted to explain the images to his mom ... with kidney disease have thin bones with low density and increased risk of fracture. Today, Leonard's team is using both DXA scanning and their high ... read more

Vitamin D

Not surprisingly therefore, most people do think of vitamin D as a bone vitamin, when in fact it's actually a hormone and may be able to be used on the skin to treat psoriasis and could have ... decrease their risk of hip fracture and wrist fracture ... read more

Can hormone therapy help protect the brain?

The timing hypothesis has also been used to explain a similar pattern in the study results on hormone use and heart disease, a condition that appears to share some risk factors and mechanisms with ... which could have shaped the study results. read more


Pulling strings further, as I explain in this article, leads to an understanding as to why antidepressants are associated with an increased risk of breast cancer ... is a clear mechanism that could cause these dangerous strokes in the brain. read more

Study questions association between common heartburn drugs and risk of pneumonia

urinary tract infections and skin infections – for which no plausible mechanism could explain an increased risk caused by PPIs. The results showed that patients taking PPIs were more likely than nonusers to have osteoarthritis, chest pain, urinary tract ... read more

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