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AMPK Activator O304 A Novel Potential Treatment For Diabetic Kidney Disease - Latest News


AMPK Activator O304 A Novel Potential Treatment for Diabetic Kidney Disease

Globally ~40% of type 2 diabetes (T2D) patients develop diabetic kidney disease (DKD), and diabetes is the leading cause of end stage renal disease, requiring dialysis or a kidney transplant. Standard ... read more

Faulty sensing: Cellular energy sensor linked to the progression of chronic kidney disease

Chronic kidney disease (CKD), an affliction ... author Eisei Sohara. "However, AMPK activation via AMP-independent mechanisms can break this cycle and represents a novel therapeutic approach for the t... read more

A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes

This project aims to close the gap to the market for a small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novel first-in-class drug for the treatment ... disease. The num... read more

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

1-Adrenergic Receptor: A POTENTIAL ... a Novel Insulin Receptor Potentiator that Elicits a Rapid-Onset and Durable Improvement in Glucose Homeostasis in Animal Models of Type 2 Diabetes Defining the C... read more


Does Esperion Therapeutics Have A Blockbuster With ETC-1002?

In rare and extreme cases, muscle breakdown, kidney failure ... cardiovascular disease risk. This investigative drug has blockbuster potential because patients with hypercholesterolemia and a history ... read more

Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity

Mitochondrial dysfunction contributes to the pathology of human health conditions, including various kidney diseases ... For example, long-term treatment with activators of 5′-AMP activated kinase (AM... read more

Metformin is a novel suppressor for transforming growth factor (TGF)-β1

Thus, our results indicate that metformin is a novel TGF-β suppressor with therapeutic potential for numerous diseases ... supports the clinical use of metformin as a treatment for numerous diseases b... read more

Study identifies potential drug targets for muscular dystrophy treatments

This week in the JCI, a study led by Perrine Castets at the University of Basel has demonstrated that pharmacological treatments targeting AMPK and ... When MD1 mice were treated with a drug that acti... read more

Poxel's Anti-diabetic Imeglimin Confirms Its Unique Mechanism of Action in Type 2 Diabetic Patients

No other single agent impacts the three main organs involved in this chronic disease, which means Imeglimin can be combined with any current diabetes treatments. This potential was ... A direct activa... read more



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